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Crispr Gene Editing Can Cause Unwanted Changes in Human Embryos, Study Finds – The New York Times

Instead of addressing genetic mutations, the Crispr machinery prompted cells to lose entire chromosomes.

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In 2017, a team of researchers led by Shoukhrat Mitalipov, a geneticist at Oregon Health and Science University in Portland, reported that human embryos carrying a mutation could be coaxed into this process without a synthetic template. The researchers generated embryos from a union between two cells: a sperm carrying a mutation that can make it harder for the heart to pump blood, and an egg with a healthy version of the gene. Dr. Mitalipov and his team used Crispr-Cas9 to cut the broken copy of…

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